منابع مشابه
Caspase 8 Promotes Peripheral Localization and Activation of Rab5*S⃞
Caspase 8 is a cysteine protease that initiates apoptotic signaling via the extrinsic pathway in a manner dependent upon association with early endosomes. Previously, we identified caspase 8 as an effector of migration, promoting motility in a manner dependent upon phosphorylation on Tyr-380 by Src family kinases and its subsequent association with Src homology 2 domain-containing proteins. Her...
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1. Centre National de Recherche Scientifique, Unité Mixte de Recherche 8126, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France. 2. University Hospital CHUV, Pediatric Oncology Research, Department of Pediatrics, Lausanne, Switzerland. § Current address: Lawrence Berkeley National Lab, 1 Cyclotron Rd., MS-977-225A, University of California, Berkeley, CA 94720, USA 3....
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Sendai virus (SV) infection and replication lead to a strong cytopathic effect with subsequent death of host cells. We now show that SV infection triggers an apoptotic program in target cells. Incubation of infected cells with the peptide inhibitor z-VAD-fmk abrogated SV-induced apoptosis, indicating that proteases of the caspase family were involved. Moreover, proteolytic activation of two dis...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2013
ISSN: 1934-1792
DOI: 10.3180/react_1503.5